Defining within- host SARS- CoV- 2 RNA viral load kinetics during acute COVID- 19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta- analysis

Pan, Daniel, Christopher, Martin, Joshua, Nazareth, Shirley, Sze, Amani, Al- Oraibi, Mayuri, Gogoi, Natalia, Grolmusova, Pip, Divall, Jonathan, Decker ORCID: 0000-0001-5904-7311, Eve, Fletcher, Caroline, Williams, James, Hay, Rebecca F, Baggaley, Anne L, Wyllie, Iain, Stephenson, Erol, Gaillard, Laura B, Nellums, Tristan William, Clark, Jonathan Nguyen, Van- Tam, Benjamin J, Cowling, T. Déirdre, Hollingsworth, Laura, Gray, Michael, Barer and Manish, Pareek (2024) Defining within- host SARS- CoV- 2 RNA viral load kinetics during acute COVID- 19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta- analysis. BMJ Open. doi:10.1136/bmjopen-2024-085127 (In Press)

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Abstract

Introduction Understanding how RNA viral load changes (viral load kinetics) during acute infection in SARS- CoV- 2 can help to identify when and which patients are most infectious. We seek to summarise existing data on the longitudinal RNA viral load kinetics of SARS- CoV- 2 sampled from different parts of the respiratory tract (nose, nasopharynx, oropharynx, saliva and exhaled breath) and how this may vary with age, sex, ethnicity, immune status, disease severity, vaccination, treatment and virus variant.

Item Type: Article
Article Type: Article
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
Divisions: Schools and Research Institutes > School of Health and Social Care
Depositing User: Jonathan Decker
Date Deposited: 17 Dec 2024 16:07
Last Modified: 17 Dec 2024 16:15
URI: https://eprints.glos.ac.uk/id/eprint/14637

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