Tools
Tools
Stoner, Lee, Stone, Keeron J 
ORCID: 0000-0001-6572-7874, Zieff, Gabriel H, Blackwell, Jade, Diana, Jake, Credeur, Daniel P., Paterson, Craig ORCID: 0000-0003-3125-9712 and Fryer, Simon M ORCID: 0000-0003-0376-0104
(2020)
Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing.
Vascular Medicine, 25 (5).
pp. 419-426.
doi:10.1177/1358863X20926588
|
Text (Published version)
8454-Stone-(2020)-Endothelium-function-dependence-of-acute-changes.pdf - Published Version Available under License Creative Commons Attribution Non-commercial 4.0. Download (1MB) | Preview |
Abstract
Flow-mediated slowing (FMS), defined as the minimum pulse wave velocity (PWVmin) during reactive hyperemia, is potentially a simple, user-objective test for examining endothelial function. The purpose of the current study was to determine the effects of a known endothelial dysfunction protocol on arm PWV and PWVmin. Complete data were successfully collected in 22 out of 23 healthy adults (23.8 years [SD 4.1], 16 F, 22.8 kg/m2 [SD 2.8]). Local endothelial dysfunction was induced by increasing retrograde shear stress in the upper arm, through inflation of a distal (forearm) tourniquet to 75 mmHg, for 30 min. Pre- and post-endothelial dysfunction, PWV was measured followed by simultaneous assessment of PWVmin and flow-mediated dilation (FMD). PWV was measured between the upper arm and wrist using an oscillometric device, and brachial FMD using ultrasound. FMD (%) and PWVmin (m/s) were calculated as the maximum increase in diameter and minimum PWV during reactive hyperemia, respectively. Endothelial dysfunction resulted in a large effect size (ES) decrease in FMD (∆ = −3.10%; 95% CI: –4.15, –2.05; ES = −1.3), and a moderate increase in PWV (∆ = 0.38 m/s; 95% CI: 0.07, 0.69; ES = 0.5) and PWVmin (∆ = 0.16 m/s; 95% CI: 0.05, 0.28; ES = 0.6). There was a large intra-individual (pre- vs post-endothelial dysfunction) association between FMD and PWVmin (r = −0.61; 95% CI: –0.82, –0.24). In conclusion, acute change in PWV and PWVmin are at least partially driven by changes in endothelial function.
| Item Type: | Article |
|---|---|
| Article Type: | Article |
| Additional Information: | This is the accepted version of an article published in final form as Stoner, L., Stone, K., Zieff, G., Blackwell, J., Diana, J., Credeur, D. P., Fryer, S. (2020). Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing. Vascular Medicine. https://doi.org/10.1177/1358863X20926588 © SAGE Publications |
| Uncontrolled Keywords: | Arterial stiffness; Endothelial dysfunction; Flow-mediated dilation; Measurement validity; Retrograde shear stress |
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
| Divisions: | Schools and Research Institutes > School of Education and Science |
| Research Priority Areas: | Health, Life Sciences, Sport and Wellbeing |
| Depositing User: | Rhiannon Goodland |
| Date Deposited: | 11 Sep 2020 10:16 |
| Last Modified: | 31 Aug 2023 09:07 |
| URI: | https://eprints.glos.ac.uk/id/eprint/8454 |
University Staff: Request a correction | Repository Editors: Update this record
