The use of shear rate–diameter dose–response curves as an alternative to the flow-mediated dilation test

Wu, Brian, Credeur, Daniel, Fryer, Simon M ORCID: 0000-0003-0376-0104 and Stoner, Lee (2015) The use of shear rate–diameter dose–response curves as an alternative to the flow-mediated dilation test. Medical Hypotheses, 84 (2). pp. 85-90. doi:10.1016/j.mehy.2014.12.014

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Abstract

The brachial artery flow-mediated dilation test (FMD) is the non-invasive gold-standard used to test endothelial function. Reduced FMD precedes the development of atherosclerosis and provides an early marker for predicting future cardiovascular disease events. Although, this test is of high potential, it is somewhat limited by poor reproducibility. By utilizing hand warming and grip exercise combined with hierarchical linear modeling, shear rate–diameter dose–response curves may provide a novel and more accurate way to assess endothelial function in humans. Shear rate–diameter dose–response curves could potentially improve upon the traditional FMD measurement and serve as a superior clinical and research tool for assessing cardiovascular disease risk in a variety of populations. The current paper presents testable hypotheses and methodology for assessing the validity and reliability of an alternative to the current FMD test.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Sport physiology
Subjects:	Q Science > QP Physiology > QP301.H75 Physiology. Sport R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Anne Pengelly
Date Deposited:	20 Jul 2015 13:15
Last Modified:	31 Aug 2023 09:09
URI:	https://eprints.glos.ac.uk/id/eprint/2466

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