Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome.

Richards, Cory T ORCID: https://orcid.org/0000-0003-3605-7044, Griffiths, Thomas D, Adams, Zoe H, Wright, Melissa E, Davies, Saajan, Talbot, Jack S, Broad-Thomas, Lauren, Esteban, Diego García, Steventon, Jessica J, Brassard, Patrice, Murphy, Kevin, James, Philip E, Rees, D Aled and Lord, Rachel N (2025) Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome. Clinical Endocrinology. doi:10.1111/cen.70061 (In Press)

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Abstract

OBJECTIVE Despite an increased cerebrovascular disease risk, the impact of Polycystic Ovary Syndrome (PCOS) on cerebrovascular haemodynamics and function is unknown. This study characterised cerebrovascular haemodynamics and function in women with PCOS versus healthy controls. DESIGN Case-control study. PATIENTS Fifteen women with PCOS (age: 31 ± 6 years; body mass index (BMI): 31.8 ± 5.7 kg/m²) and 16 controls (age: 30 ± 7 years; BMI: 29.9 ± 5.5 kg/m²). MEASUREMENTS Resting global cerebral blood (CBF) was assessed by 3T MRI. Middle- and posterior cerebral artery blood velocities (MCAv, PCAv) were measured by Doppler ultrasound and pulsatility index (MCA_PI, PCA_PI) calculated. Neurovascular coupling (NVC), internal carotid artery cerebrovascular reactivity (CVR_CO2) and dynamic cerebral autoregulation (dCA) directional sensitivity were assessed using a visual stimulus, 6% fixed-inspired CO₂ and repeated squat-stand manoeuvres, respectively. RESULTS Resting CBF (PCOS: 57.2 ± 7.5 ml/100 g/min; controls: 61.6 ± 11.6 ml/100 g/min, p = 0.25) and MCAv, PCAv, MCA_PI and PCA_PI (all p > 0.05) were similar between groups. NVC (14 ± 4.9% vs. 13 ± 3.4%, p = 0.45), CVR_CO2 (5.1 ± 1.9% vs. 6.5 ± 2.9%, p = 0.20) and dCA directional sensitivity were similar between groups. However, women with PCOS had elevated relative PCA_PI during NVC (PCOS: 12.0 ± 5.6% vs. controls: 7.0 ± 3.8%, p = 0.04), and impaired vasodilation of the internal carotid artery during CVR_CO2 (PCOS: -0.10 ± 0.22 mm vs. controls: 0.18 ± 0.24 mm, p < 0.01). CONCLUSIONS Cerebrovascular function is largely preserved in women with PCOS, although elevated arterial pulsatility and impaired vasodilatory response to carbon dioxide may indicate early endothelial dysfunction in the cerebral vasculature. Larger studies are needed to confirm this in view of our limited study power.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Cerebral blood flow; Cerebrovascular Circulation; Doppler Ultrasonography; Magnetic Resonance Imaging; Neurovascular Coupling; Polycystic Ovary Syndrome
Subjects:	Q Science > QP Physiology
Divisions:	Schools and Research Institutes > School of Education, Health and Sciences
Depositing User:	Cory Richards
Date Deposited:	01 Dec 2025 14:10
Last Modified:	06 Dec 2025 08:00
URI:	https://eprints.glos.ac.uk/id/eprint/15589

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