Beyond the Heart: The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification

Cortiana, Viviana, Vaghela, Hetvee, Bakhle, Rahul, Santhosh, Tony, Kaiwan, Oroshay, Tausif, Aalia, Goel, Ashish, Suhail, Mohammed K., Patel, Neil, Akram, Omar, Kaka, Nirja, Sethi, Yashendra and Moinuddin, Arsalan ORCID: 0000-0002-4242-1714 (2024) Beyond the Heart: The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification. Diagnostics, 14 (21). p. 2349. doi:10.3390/diagnostics14212349

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Abstract

Coronary artery calcium scoring (CACS), a non-invasive measure of coronary atherosclerosis, has significantly enhanced cardiovascular (CV) risk assessment and stratification in asymptomatic individuals. More recently, a higher score for CAC has been associated with an increased risk of non-CV diseases and all-cause mortality. This review consolidated evidence supporting the role of CAC in assessing non-CV diseases, emphasizing its potential in early diagnosis and prognosis. We observed a strong association between CACS and non-CV diseases, viz., chronic obstructive pulmonary disease, pulmonary embolism, pneumonia, diabetes, chronic kidney disease, osteoporosis, metabolic dysfunction-associated steatotic liver disease, nephrolithiasis, stroke, dementia, malignancies, and several autoimmune diseases. Also, CAC may aid in evaluating the risk of CV conditions developing secondary to the non-CV diseases mentioned earlier. Further evidence from prospective studies, intervention trials, and population-based behavioral studies is needed to establish CAC cutoff values and explore preventative care applications, facilitating their broader integration into healthcare practices.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Coronary artery calcification; Coronary artery calcium score; Calcium score; Prognostic factors; Cardiovascular disease
Subjects:	R Medicine > R Medicine (General)
Divisions:	Schools and Research Institutes > School of Education and Science
Depositing User:	Charlotte Crutchlow
Date Deposited:	20 Nov 2024 10:50
Last Modified:	20 Nov 2024 12:20
URI:	https://eprints.glos.ac.uk/id/eprint/14568

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