Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis

Hulin-Curtis, Sarah L ORCID: https://orcid.org/0000-0003-0889-964X, Bidwell, JL and Perry, MJ (2011) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. International Journal of Immunogenetics, 39 (2). pp. 106-109. doi:10.1111/j.1744-313X.2011.01060.x

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Abstract

We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

Item Type:	Article
Article Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Schools and Research Institutes > School of Education, Health and Sciences
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Sarah Curtis
Date Deposited:	18 Jun 2024 13:32
Last Modified:	05 Aug 2025 09:54
URI:	https://eprints.glos.ac.uk/id/eprint/14154

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