Acinetobacter baumannii Sampled from Cattle and Pigs Represent Novel Clones

Mateo-Estrada, Valeria, Vali, Leila ORCID: 0009-0000-7740-3703, Hamouda, Ahmed, Evans, Benjamin A. and Castillo-Ramirez, Santiago (2022) Acinetobacter baumannii Sampled from Cattle and Pigs Represent Novel Clones. Microbiology Spectrum, 10 (4). doi:10.1128/spectrum.01289-22

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Text 13566 Mateo-Estrada, Vali, Hamouda, Evans, Castillo-Ramirez (2022) Acinetobacter baumannii sampled from cattle and pigs represent novel clones.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (1MB) | Preview

Abstract

Acinetobacter baumannii is a very important human pathogen. Nonetheless, we know very little about nonhuman isolates of A. baumannii. Here, we determine the genomic identity of 15 Scottish cattle and pig isolates, as well as their antibiotic and virulence genetic determinants, and compare them with 148 genomes from the main human clinical international clones. Our results demonstrate that cattle and pig isolates represent novel clones well separated from the major international clones. Furthermore, these new clones showed fewer antibiotic resistance genes and may have fewer virulence genes than human clinical isolates. IMPORTANCE Over the last decades, huge amounts of information have been obtained for clinical isolates of A. baumannii and the clones they belong to. In contrast, very little is known about the genomic identity and the genomic basis for virulence and resistance of animal isolates. To fulfil this gap, we conducted a genomic epidemiology study of 15 Scottish cattle and pig isolates in the context of almost 150 genomes belonging to the main international clones of A. baumannii. Our findings show that these animal isolates represent novel clones clearly different from the major international clones. Furthermore, these new clones are distinct in nature considering both antibiotic resistance and virulence when compared with their human clinical counterparts.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Genome epidemiology; Acinetobacter baumannii; Antibiotic resistance; Animal isolates; Bacterial clones; One Health
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Place, Environment and Community
Depositing User:	Anna Kerr
Date Deposited:	15 Dec 2023 12:52
Last Modified:	15 Jul 2024 13:45
URI:	https://eprints.glos.ac.uk/id/eprint/13566

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