Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial

Fryer, Simon M ORCID: 0000-0003-0376-0104, Stone, Keeron J ORCID: 0000-0001-6572-7874, Paterson, Craig ORCID: 0000-0003-3125-9712, Brown, Meghan A ORCID: 0000-0003-3260-977X, Faulkner, James, Lambrick, Danielle M, Credeur, Daniel, Zieff, Gabriel H, Martinez Aguirre-Betolaza, Aitor and Stoner, Lee (2021) Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial. Hypertension Research, 44. pp. 1332-1340. doi:10.1038/s41440-021-00708-z

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Abstract

Background and aims: Independently, prolonged uninterrupted sitting and the consumption of a meal high in saturated fats acutely disrupt normal cardiovascular function. Currently the acute effects of these behaviours performed in combination on arterial stiffness, a marker of cardiovascular health, is unknown. This study sought to determine the effect of consuming a high-fat meal (Δ= 51 g fat) in conjunction with prolonged uninterrupted sitting (180 min) on measures of central and peripheral arterial stiffness. Methods: Using a randomized crossover design, thirteen young healthy males consumed a high-fat (61 g) or low-fat (10 g) meal before 180 min of uninterrupted sitting. Carotid-femoral (cf-) and femoral-ankle (fa-) pulse wave velocity (PWV), aortic-femoral stiffness gradient (af-SG), superficial femoral PWV beta (β), and oscillometric pulse wave analysis outcomes were assessed pre and post sitting. Results: cfPWV increased significantly more following the high-fat (mean difference [MD]= 0.59 m·s-1) when compared to the low-fat (MD= 0.2 m·s-1) meal, with no change in faPWV in either condition. The af-SG significantly decreased (worsened) (ηp2= 0.569) overtime in high and low-fat conditions (ratio= 0.1 and 0.1 respectively). Superficial femoral PWVβ significantly increased over time in high- and low-fat conditions (ηp2= 0.321; 0.8 and 0.4 m·s-1 respectively). A significant interaction found that triglycerides increased over time in the high fat trial only (ηp2= 0.761). There were no significant changes in blood pressures. Conclusions: Consuming a high-fat meal prior to 180 min of uninterrupted sitting augments markers of cardiovascular disease risk more than sitting following a low-fat meal.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Vascular function; Sedentary behaviour; Dietary behaviour; Hypertension
Subjects:	G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports Q Science > QP Physiology
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Rhiannon Goodland
Date Deposited:	29 Jun 2021 11:53
Last Modified:	31 Aug 2023 09:07
URI:	https://eprints.glos.ac.uk/id/eprint/9903

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