Cerebrovascular function response to prolonged sitting combined with a high‐glycemic index meal: A double‐blind, randomized cross‐over trial

Burnet, Kathryn, Blackwell, Jade, Kelsch, Elizabeth, Hanson, Erik D., Stone, Keeron J ORCID: 0000-0001-6572-7874, Fryer, Simon M ORCID: 0000-0003-0376-0104, Credeur, Daniel, Palta, Priya and Stoner, Lee (2021) Cerebrovascular function response to prolonged sitting combined with a high‐glycemic index meal: A double‐blind, randomized cross‐over trial. Psychophysiology, 58 (8). e13830. doi:10.1111/psyp.13830

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Abstract

Acute prolonged sitting leads to cerebrovascular disruptions. However, it is unclear how prolonged sitting interacts with other common behaviors, including high-(HGI) and low-glycemic index (LGI) meals. Using a double-blind randomized cross-over design, this study evaluated the effects of prolonged (3 hr) sitting, with a high-(HGI; GI: 100) or low-glycemic index (LGI; GI: 19) meal on total brain blood flow (QBrain) and executive function. Eighteen young, healthy, active participants (22.6 [3.1] y, 33% F, 24.3 [3.7] kg/m2) sat for 3 hr after consuming an HGI or LGI meal. Using Doppler ultrasound to measure internal carotid (ICA) and vertebral (VA) artery blood flow, QBrain was calculated: (ICA blood flow + VA blood flow) × 2. Executive function was assessed using the Stroop Test and Trail Making Test—Part B. Brain fog was measured using a modified Borg Category Scale with Ratio properties (CR10). Following 3 hr of sitting, there was a significant decrease in QBrain with time (p = .001, ES = −0.26), though there were nonsignificant interaction (p = .216) and condition effects (p = .174). Brain fog increased (p = .024, ES = 0.27) and Stroop reaction time worsened with time (p = .001, ES: −0.40), though there were nonsignificant condition effects for brain fog (p = .612) and the Stroop test (p = .445). There was a nonsignificant condition effect (p = .729) for the Trail Making Test—Part B, but completion time improved with time (p = .001, ES = −0.40). In conclusion, 3 hr of prolonged sitting decreases QBrain and executive function independent of glycemic index in young, healthy adults.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Doppler ultrasound; Executive function; Glycemic index; Sedentary; Total brain blood flow
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Schools and Research Institutes > School of Natural, Social and Sports Sciences > Sports Sciences
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 06 May 2021 13:14
Last Modified: 28 Sep 2022 10:08
URI: https://eprints.glos.ac.uk/id/eprint/9647

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