The aortic-femoral arterial stiffness gradient: an Atherosclerosis Risk In the Communities (ARIC) study

Stone, Keeron J ORCID: 0000-0001-6572-7874, Fryer, Simon M ORCID: 0000-0003-0376-0104, Meyer, Michelle L., Kucharska-Newton, Anna, Faulkner, James, Zieff, Gabriel, Paterson, Craig ORCID: 0000-0003-3125-9712, Credeur, Daniel, Matsushita, Kunihiro, Hughes, Timothy, Tanaka, Hirofumi and Stoner, Lee (2021) The aortic-femoral arterial stiffness gradient: an Atherosclerosis Risk In the Communities (ARIC) study. Journal of Hypertension, 39 (7). pp. 1370-1377. doi:10.1097/HJH.0000000000002808

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Abstract

The aortic to femoral arterial stiffness gradient (af-SG) may be a novel measure of arterial health and cardiovascular disease (CVD) risk, but its association with CVD risk factors and CVD status, and whether or not they differ from the referent measure, carotid-femoral pulse-wave velocity (cfPWV), is not known. Accordingly, we compared the associations of the af-SG and cfPWV with, (1) age and traditional CVD risk factors, and (2) CVD status. We evaluated 4,183 older-aged (75.2±5.0 years) men and women in the community-based Atherosclerosis Risk in Communities (ARIC) Study. cfPWV and femoral-ankle PWV (faPWV) were measured using an automated cardiovascular screening device. The af-SG was calculated as faPWV divided by cfPWV. Associations of af-SG and cfPWV with age, CVD risk factors (age, body mass index, blood pressure, heart rate, glucose and blood lipid levels) and CVD status (hypertension, diabetes, coronary heart disease, heart failure, stroke) were determined using linear and logistic regression analyses. (1) The af-SG and cfPWV demonstrated comparable associations with age and CVD risk factors, except body mass index. (2) A low af-SG was associated with diabetes, coronary heart disease, heart failure and stroke, whilst a high cfPWV was only associated with hypertension. Although future studies are necessary to confirm clinical utility, the af-SG is a promising tool that may provide a unique picture of hemodynamic integration and identification of CVD risk when compared to cfPWV.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Pulse-wave velocity ration; Risk factors; Cardiovascular disease
Subjects:	R Medicine > RA Public aspects of medicine > RA645.A-Z Individual diseases or groups of diseases, A-Z Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Rhiannon Goodland
Date Deposited:	21 Jan 2021 14:57
Last Modified:	31 Aug 2023 09:07
URI:	https://eprints.glos.ac.uk/id/eprint/9291

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