Acute changes in carotid-femoral pulse-wave velocity are tracked by heart-femoral-pulse-wave velocity

Stone, Keeron J ORCID: 0000-0001-6572-7874, Fryer, Simon M ORCID: 0000-0003-0376-0104, Faulkner, James, Meyer, Michelle L., Zieff, Gabriel H, Paterson, Craig ORCID: 0000-0003-3125-9712, Burnet, Kathryn, Kelsch, Elizabeth, Credeur, Daniel, Lambrick, Danielle M and Stoner, Lee (2021) Acute changes in carotid-femoral pulse-wave velocity are tracked by heart-femoral-pulse-wave velocity. Frontiers in Cardiovascular Medicine, 7. art 592834. doi:10.3389/fcvm.2020.592834

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Background: Carotid-femoral pulse-wave velocity (cfPWV) is the reference standard measure of central arterial stiffness. However, it requires assessment of the carotid artery, which is technically challenging, and subject-level factors, including carotid artery plaque, may confound measurements. A promising alternative that overcomes these limitations is heart-femoral PWV (hfPWV), but it is not known to what extent changes in cfPWV and hfPWV are associated. Objectives: To determine, (1) the strength of the association between hfPWV and cfPWV; and (2) whether change in hfPWV is associated with change in cfPWV when central arterial stiffness is perturbed. Methods: Twenty young, healthy adults (24.0 [SD: 3.1] years, 45% female) were recruited. hfPWV and cfPWV were determined using Doppler ultrasound at baseline and following a mechanical perturbation in arterial stiffness (120mmHg thigh occlusion). Agreement between the two measurements was determined using mixed-effects regression models and Bland-Altman analysis. Results: There was, (1) strong (ICC >0.7) agreement between hfPWV and cfPWV (ICC= 0.82, 95%CI: 0.69,0.90), and, (2) very strong (ICC >0.9) agreement between change in hfPWV and cfPWV (ICC = 0.92, 95%CI: 0.86,0.96). cfPWV was significantly greater than hfPWV at baseline and during thigh occlusion (both P <0.001). Inspection of the Bland-Altman plot, comparing cfPWV and corrected hfPWV, revealed no measurement magnitude bias. Discussion: The current findings indicate that hfPWV and cfPWV are strongly associated, and that change in cfPWV is very strongly associated with change in hfPWV. hfPWV may be a simple alternative to cfPWV in the identification of cardiovascular risk in clinical and epidemiological settings.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Arterial stiffness; Measurement; Vascular risk; Doppler ultrasound; Pulse-transit time
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 08 Jan 2021 14:55
Last Modified: 31 Aug 2023 09:07

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