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Emerson, Dawn M., Chen, Stephen C.L., Torres-McGehee, Toni M., Pfeifer, Craig E. 
ORCID: 0000-0002-0635-4956, Emerson, Charles C. and Davis, J. Mark
(2021)
An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment.
Sports Medicine and Health Science, 3 (4).
pp. 243-251.
doi:10.1016/j.smhs.2021.08.004
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Text (Published version)
8887-Pfeifer-(2021)-An-acute-naproxen-dose-does-not-affect.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1MB) | Preview |
Abstract
Non-steroidal anti-inflammatory drugs’ anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature (Tc) increases during exercise. We utilized a double-blind, randomized, and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose (3–220 mg naproxen pills) and placebo (0 mg naproxen) on Tc and plasma interleukin-6 (IL-6) concentrations during cycling in a hot or ambient environment. Participants (n = 11; 6 male, 5 female; age = 27.8 ± 6.5 years, weight = 79.1 ± 17.9 kg, height = 177 ± 9.5 cm) completed 4 conditions: 1) placebo and ambient (Control); 2) placebo and heat (Heat); 3) naproxen and ambient (Npx); and 4) naproxen and heat (NpxHeat). Dependent measures were taken before, during, and immediately after 90 min of cycling and then 3 h after cycling. Overall, Tc significantly increased pre- (37.1 ± 0.4 °C) to post-cycling (38.2 ± 0.3 °C, F1.7,67.3 = 150.5, p < 0.001) and decreased during rest (37.0 ± 0.3 °C, F2.0,81.5 = 201.6, p < 0.001). Rate of change or maximum Tc were not significantly different between conditions. IL-6 increased pre- (0.54 ± 0.06 pg/ml) to post-exercise (2.46 ± 0.28 pg/ml, p < 0.001) and remained significantly higher than pre-at 3 h post- (1.17 ± 0.14 pg/ml, 95% CI = −1.01 to −0.23, p = 0.001). No significant IL-6 differences occurred between conditions. A 24-h, over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.
| Item Type: | Article |
|---|---|
| Article Type: | Article |
| Uncontrolled Keywords: | Cytokine; Exertional heat illness; NSAIDs; Thermoregulation; Exercise |
| Subjects: | Q Science > QP Physiology > QP301.H75 Physiology. Sport R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Schools and Research Institutes > School of Education and Science |
| Research Priority Areas: | Health, Life Sciences, Sport and Wellbeing |
| Depositing User: | Craig Pfeifer |
| Date Deposited: | 15 Sep 2021 13:29 |
| Last Modified: | 31 Aug 2023 09:07 |
| URI: | https://eprints.glos.ac.uk/id/eprint/8887 |
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