Cardiovascular consequences of skeletal muscle impairments in breast cancer

Zieff, Gabriel H, Wagoner, Chad W, Paterson, Craig ORCID: 0000-0003-3125-9712, Pagan Lassalle, Patricia and Lee, Jordan T (2020) Cardiovascular consequences of skeletal muscle impairments in breast cancer. Sports, 8 (6). p. 80. doi:10.3390/sports8060080

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Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20%–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk.

Item Type: Article
Article Type: Article
Additional Information: Zieff, G.H.; Wagoner, C.W.; Paterson, C.; Lassalle, P.P.; Lee, J.T. Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer. Sports 2020, 8, (6) article number 80.
Uncontrolled Keywords: Skeletal muscle; Breast cancer; Aerobic exercise; Resistance training
Subjects: Q Science > QM Human anatomy
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology > RM695 Physical medicine. physical therapy including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 03 Jun 2020 14:21
Last Modified: 31 Aug 2023 09:07

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