A metabolically healthy profile is a transient stage when exercise and diet is not supervised: long-term effects in the EXERDIET-HTA study

Corres, Pablo, Fryer, Simon M ORCID: 0000-0003-0376-0104, Aguirre-Betolaza, Aitor, Gorostegi-Anduaga, Ilargi, Arritabel-Imaz, Inaki, Pérez-Asenjo, Javier, Francisco-Terreros, Silvia, Saracho, Ramon and Maldonado-Martin, Sara (2020) A metabolically healthy profile is a transient stage when exercise and diet is not supervised: long-term effects in the EXERDIET-HTA study. International Journal of Environmental Research and Public Health, 17 (8). p. 2830. doi:10.3390/ijerph17082830

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Metabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity and physically inactive. To become and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment. The aims of the study were 1) to determine differences in metabolic profiles of overweight/obese, physically inactive individuals with HTN following a 16-week (POST) supervised aerobic exercise training (SupExT) intervention with an attentional control (AC) group and, 2) to determine whether the changes observed were maintained following six months (6M) of unsupervised time. Participants (n=219) were randomly assigned into AC or SupExT groups. All participants underwent a hypocaloric diet. At POST all participants received diet and physical activity advice for the following 6M, with no supervision. All measurements were assessed pre-intervention (PRE), POST, and after 6M. From PRE to POST, MUO participants became MHO with improved (P<0.05) total cholesterol (TC, ∆=-12.1 mg/dL), alanine aminotransferase ∆=-8.3 U/L), glucose (∆=-5.5 mg/dL), C-reactive protein (∆=-1.4 mg/dL), systolic blood pressure (SBP) and CRF compared to unhealthy optimal cut-off values. However, after 6M, TC, glucose, and SBP returned to unhealthy values (P<0.05). In a non-physically active population with obesity and HTN, a 16-week SupExT and diet intervention significantly improves cardiometabolic profile from MUO to MHO. However, after 6M of no supervision, participants returned to MUO. The findings of this study highlight the need for regular, systematic and supervised diet and exercise programs to avoid subsequent declines in cardiometabolic health.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Obesity; Hypertension; Inactivity; Supervised exercise
Subjects: Q Science > QM Human anatomy
R Medicine > RM Therapeutics. Pharmacology > RM695 Physical medicine. physical therapy including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 24 Apr 2020 10:30
Last Modified: 31 Aug 2023 09:07
URI: https://eprints.glos.ac.uk/id/eprint/8315

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