Validity of single‐point assessments for determining leg pulse‐wave velocity in sitting and supine positions

Fryer, Simon M ORCID: 0000-0003-0376-0104, Stone, Keeron J ORCID: 0000-0001-6572-7874, Zieff, Gabriel, Faulkner, James, Credeur, Daniel and Stoner, Lee (2020) Validity of single‐point assessments for determining leg pulse‐wave velocity in sitting and supine positions. Clinical Physiology and Functional Imaging, 40 (3). pp. 157-164. doi:10.1111/cpf.12616

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Text (peer-reveiwed article) 7081 Fryer (2019) Validity of single-point assessments for determining leg pulse-wave velocity in sitting and supine positions.pdf - Accepted Version Available under License All Rights Reserved. Download (249kB) | Preview

Abstract

There has been a great deal of interest into the effects of prolonged sitting on lower limb vascular function. However, most studies use flow mediated dilation which is technically challenging. A simpler technique is pulse wave velocity (PWV) which can be estimated at any single arterial site of interest using a number of different calculations [Bramwell-hill (PWVBH ), β-stiffness index (PWVß ), and blood flow (PWVBF )]. Findings from this technique would be better inferred if they compare to a standard criterion 2-point PWV assessment. The current study used ultrasound to determine which estimation of single-point PWV is most valid. The criterion was traditional ECG-gated 2-point (superficial femoral [SF]-posterior tibialis [PT]) PWV. Single-point estimates were calculated at the SF and PT arteries in both supine and seated positions. Single-point PWV was considered valid if the aSEE was <1.0m·s. Findings show that for both postural positions, the absolute standard error of estimates (aSEE) criterion of <1.0 m·s was not achieved in either the PT or SF arteries using any of the single-point PWV calculations. However, single-point calculations consistently demonstrated the lowest error at the SF artery using PWVß in both supine (SF aSEE = 1.7 vs. PT 2.7m·s) and seated (SF aSEE = 1.5 vs. PT 3.0m·s) positions. All single-point ΔPWV (supine - seated) calculations were higher in sitting, with PWVß having the closest agreement (ΔSF aSEE 1.7m·s) to the 2-point criterion. Single-point PWV calculations do not directly reflect regional 2-point PWV. However, they are sensitive to change when moving from supine to seated positions.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Arterial Stiffness; Endothelial Function; Prolonged Sitting; Leg Vascular Function
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Marta Kemp
Date Deposited:	13 Jan 2020 15:43
Last Modified:	31 Aug 2023 09:07
URI:	https://eprints.glos.ac.uk/id/eprint/7904

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