Prospective Relationship between Hemispheric Lateralisation and CD4+ T Cells in Human Immunodeficiency Virus Type 1

Sumner, Rachel C ORCID: 0000-0002-2421-7146, Nowicky, Alexander V, Parton, Andrew, Wylock, Carolien, Cserjesi, Renata, Fischler, Benjamin, Lacor, Patrick and Gidron, Yori (2013) Prospective Relationship between Hemispheric Lateralisation and CD4+ T Cells in Human Immunodeficiency Virus Type 1. Neuroimmunomodulation, 21 (1). pp. 31-36. doi:10.1159/000355350

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Abstract

Objectives: Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders. Methods: Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication). Results: Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts. Conclusions: Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided.

Item Type:	Article
Article Type:	Article
Additional Information:	This is the peer-reviewed but unedited manuscript version of the following article:Sumner, Rachel C , Nowicky, Alexander V, Parton, Andrew, Wylock, Carolien, Cserjesi, Renata, Fischler, Benjamin, Lacor, Patrick and Gidron, Yori (2013) Prospective Relationship between Hemispheric Lateralisation and CD4+ T Cells in Human Immunodeficiency Virus Type 1. Neuroimmunomodulation, 21 (1). pp. 31-36. The final, published version is available at http://www.karger.com/?doi=10.1159/000355350 Non commercial use only.
Uncontrolled Keywords:	CD4, HAART, Hemispheric lateralisation, HIV, Prospective study
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Schools and Research Institutes > School of Health and Social Care
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Rachel Sumner
Date Deposited:	25 May 2016 16:32
Last Modified:	27 Jul 2023 15:34
URI:	https://eprints.glos.ac.uk/id/eprint/3546

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