There's More to Flow-Mediated Dilation Than Nitric Oxide

Stoner, Lee, Erickson, Melissa Lynn, Young, Joanna Mary, Fryer, Simon M ORCID: 0000-0003-0376-0104, Sabatier, Manning Joseph, Faulkner, James, Lambrick, Danielle Marie and McCully, Kevin Kane (2012) There's More to Flow-Mediated Dilation Than Nitric Oxide. Journal of Atherosclerosis and Thrombosis, 19 (7). pp. 589-600. doi:10.5551/jat.11973

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Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Endothelium, FMD, Shear stress, Prostacyclin, Endothelial-derived hyperpolarizing factor, Cardiovascular disease
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Anne Pengelly
Date Deposited: 20 Jul 2015 14:50
Last Modified: 31 Aug 2023 09:10

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