SP8.07 Expression of Matriptase-2 and TMPRSS serine enzymes and the connection with bone metastasis in clinical breast cancer

Xu, Zhonghang, Sanders, Andrew J ORCID: https://orcid.org/0000-0002-7997-5286, Li, Amber Xinyu, Martin, Tracey A, Davies, Eleri and Jiang, Wen G (2025) SP8.07 Expression of Matriptase-2 and TMPRSS serine enzymes and the connection with bone metastasis in clinical breast cancer. British Journal of Surgery, 112. doi:10.1093/bjs/znaf166.105

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Text 15353 Xu, Sanders, Li, Martin, Davies, Jiang (2025) SP8.07 Expression of Matriptase-2 and TMPRSS serine enzymes and the connection with bone metastatis in clinical breast cancer.pdf - Published Version Available under License All Rights Reserved. Download (68kB) | Preview

Abstract

Aims: The present study investigated the connection between the matripase/TMPRSS (Transmembrane Serine Protease) protein enzyme family, a type II serine transmembrane enzymes, and bone metastasis in clinical breast cancer. Methods: Six members of the TMPRSS family including Matriptase-1, -2, -3, TMPRSS-3, -5, -7, and -9 were evaluated for their gene expression by way of quantitative transcript analysis in a cohort of breast cancer and mammary tissues. The levels of expression were assessed against the presence of bone metastases of the patients who had a ten year followup. Statistical analysis was based on Receiver operating characteristic (ROC) method and student t test. Results: Breast cancer tissues had a significant aberrant expression of matriptase-1 (p=0.01), matriptase-2 (p=0.047) and TMPRSS5 (p=0.031), when compared with normal mammary tissues. There was not significant difference for other members between tumour and normal tissues. When the expression levels were analysed against the presence of bone metastasis, it was found that matriptase-2 was the only TMPRSS member that had a significant value in predicting bone metastasis (AUC=0.716, p=0.013) with a hazard ratio at 6.13 (95% confidence interval 1.598-23.525. p=0.008). Multifactorial model analysis demonstrated that amongst the clinical factors and key hormone receptors (including ER and ERBB family members), matriptase-2 was the only factor that independently predict bone metastasis. Conclusions: Matriptase-2, amongst the TMPRSS serine protein family members, is an independent factor in predicting bone metastasis from breast cancer. The protein which is a regulator factor for some pro-metastasis factors, thus has important value in bone metastasis.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Gene expression; Bone metastasis; Hormone receptors; Neoplasm metastasis; Roc curve; Serine; Enzymes; Neoplasms; Breast cancer; Serine proteases
Divisions:	Schools and Research Institutes > School of Education, Health and Sciences
Depositing User:	Anna Kerr
Date Deposited:	30 Sep 2025 08:44
Last Modified:	07 Oct 2025 14:30
URI:	https://eprints.glos.ac.uk/id/eprint/15353

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