The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Central and Peripheral Pulse Wave Velocity: A Systematic Review and Meta-Analysis

Moinuddin, Arsalan ORCID: https://orcid.org/0000-0002-4242-1714, Paterson, Craig ORCID: https://orcid.org/0000-0003-3125-9712, Turner, Louise A ORCID: https://orcid.org/0000-0002-0153-7075, Stone, Keeron J ORCID: https://orcid.org/0000-0001-6572-7874, Lucas, Sam, Griffith, Thomas and Fryer, Simon M ORCID: https://orcid.org/0000-0003-0376-0104 (2025) The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Central and Peripheral Pulse Wave Velocity: A Systematic Review and Meta-Analysis. Vascular Medicine. (In Press)

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Abstract

Introduction: Sedentary behavior, specifically an acute bout of prolonged uninterrupted sitting is associated with heightened cardiovascular disease (CVD) risk, with increased arterial stiffness (AS) being implicated as a principal pathophysiological mechanism. The current systematic review, with meta-analysis, aimed to consolidate the AS response to: (1) prolonged uninterrupted- and (2) interrupted-sitting, as assessed by central- and peripheral pulse wave velocity (PWV). Methods: In total, 326 articles were identified, of which 11 and 7 met inclusion criteria for objectives: (1) and (2), respectively. Mean differences (MD) and 95% confidence intervals (CI) were calculated for all trials using a three-level random-effects model, with restricted maximum likelihood (REML) estimation. The amount of heterogeneity was estimated using Cochran's Q, and Higgins I2 tests. Results: (1) Prolonged uninterrupted sitting resulted in a significant increase in carotid-femoral (cf) PWV (MD = 0.184 m/s, 95% CI = 0.098 to 0.270, p < 0.0003). (2) Interrupting bouts of prolonged sitting resulted in a significant increase in cf-PWV (MD = 0.127 m/s, 95% CI = 0.044 to 0.209, p < 0.0026), that was lower compared to the uninterrupted sitting. Conclusion: An acute bout of uninterrupted sitting appears to increase cf-PWV and whilst interrupting with brief physical activity it is of benefit; it does not fully mitigate the response.

Item Type:	Article
Article Type:	Article
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA407 Health status indicators.
Divisions:	Schools and Research Institutes > School of Education and Science
Depositing User:	Charlotte Crutchlow
Date Deposited:	03 Apr 2025 13:24
Last Modified:	10 Apr 2025 08:00
URI:	https://eprints.glos.ac.uk/id/eprint/14893

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