Moinuddin, Arsalan ORCID: https://orcid.org/0000-0002-4242-1714, Paterson, Craig
ORCID: https://orcid.org/0000-0003-3125-9712, Turner, Louise A
ORCID: https://orcid.org/0000-0002-0153-7075, Stone, Keeron J
ORCID: https://orcid.org/0000-0001-6572-7874, Lucas, Sam
ORCID: https://orcid.org/0000-0002-8713-2457, Griffith, Thomas and Fryer, Simon M
ORCID: https://orcid.org/0000-0003-0376-0104
(2025)
The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Central and Peripheral Pulse Wave Velocity: A Systematic Review and Meta-Analysis.
Vascular Medicine.
(In Press)
![]() |
Text
14893 Moinuddin et al (2025) The Effects of Acute Exposure to Prolonged Sitting.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (418kB) |
![]() |
Text
14893 Figure 1.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (453kB) |
![]() |
Text
14893 Figure 2.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (412kB) |
![]() |
Text
14893 Figure 3.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (23kB) |
![]() |
Text
14893 Figure 4.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (15kB) |
![]() |
Text
14893 Figure 5.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (20kB) |
![]() |
Text
14893 Figure 6.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (15kB) |
![]() |
Text
14893 Table 1.pdf - Accepted Version Restricted to Repository staff only until 17 October 2025. Download (149kB) |
Abstract
Introduction: Sedentary behavior, specifically an acute bout of prolonged uninterrupted sitting is associated with heightened cardiovascular disease (CVD) risk, with increased arterial stiffness (AS) being implicated as a principal pathophysiological mechanism. The current systematic review, with meta-analysis, aimed to consolidate the AS response to: (1) prolonged uninterrupted- and (2) interrupted-sitting, as assessed by central- and peripheral pulse wave velocity (PWV). Methods: In total, 326 articles were identified, of which 11 and 7 met inclusion criteria for objectives: (1) and (2), respectively. Mean differences (MD) and 95% confidence intervals (CI) were calculated for all trials using a three-level random-effects model, with restricted maximum likelihood (REML) estimation. The amount of heterogeneity was estimated using Cochran's Q, and Higgins I2 tests. Results: (1) Prolonged uninterrupted sitting resulted in a significant increase in carotid-femoral (cf) PWV (MD = 0.184 m/s, 95% CI = 0.098 to 0.270, p < 0.0003). (2) Interrupting bouts of prolonged sitting resulted in a significant increase in cf-PWV (MD = 0.127 m/s, 95% CI = 0.044 to 0.209, p < 0.0026), that was lower compared to the uninterrupted sitting. Conclusion: An acute bout of uninterrupted sitting appears to increase cf-PWV and whilst interrupting with brief physical activity it is of benefit; it does not fully mitigate the response.
Item Type: | Article |
---|---|
Article Type: | Article |
Subjects: | Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA407 Health status indicators. |
Divisions: | Schools and Research Institutes > School of Education and Science |
Depositing User: | Charlotte Crutchlow |
Date Deposited: | 03 Apr 2025 13:24 |
Last Modified: | 03 Apr 2025 13:30 |
URI: | https://eprints.glos.ac.uk/id/eprint/14893 |
University Staff: Request a correction | Repository Editors: Update this record