The impact of uninterrupted sitting on central and peripheral cardiovascular function in pre- menopausal and post-menopausal women.

Moinuddin, Arsalan ORCID: 0000-0002-4242-1714, Stone, Keeron J ORCID: 0000-0001-6572-7874, Turner, Louise A ORCID: 0000-0003-0847-2232, Paterson, Craig ORCID: 0000-0003-3125-9712, Daykin, Anne ORCID: 0000-0002-9656-856X, Lucas, Sam ORCID: 0000-0002-8713-2457, Faulkner, James and Fryer, Simon M ORCID: 0000-0003-0376-0104 (2024) The impact of uninterrupted sitting on central and peripheral cardiovascular function in pre- menopausal and post-menopausal women. European Journal of Applied Physiology. doi:10.1007/s00421-024-05502-6 (In Press)

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Independently, both prolonged uninterrupted sitting and the onset of menopause negatively impact markers of cardiovascular risk. Whether their combination augment these responses additively remains unknown. This study assessed whether prolonged uninterrupted sitting causes greater central and peripheral cardiovascular dysfunction in post-menopausal women compared to pre-menopausal women. To address this, twenty-three healthy women (13 pre-menopausal [43.77 ± 4.30 years.] and 10 post-menopausal [57.20 ± 8.55 years.]) sat uninterrupted for 2-hours. Carotid-femoral pulse wave velocity (cf-PWV), pulse wave analysis (PWA), lower-limb venous pooling (HHb), and calfcircumference were assessed pre-and post-sitting using general linear mixed models, with age as a covariate. Changes in MAP over time (both between and within groups) was assessed using a two-way repeated-measures-ANOVA. There were no significant interactions for any outcome measures. However, for cf-PWV, there was a significant main effect of group (Δ = 0.854 ± 0.354 m·s-1; p =0.026, ηp2 =0.707). For PWA, only heart rate (HR) and pressure forwards (Pf) showed significant main effects of time [Δ = 6 ± 1 bts-min-1, p < 0.001, ηp2 = 0.861] and group [Δ = 3.893 ± 1.450 mmHg, p = 0.016, ηp2 = 0.271] respectively. Both HHb (Δ = 2.737 ± 0.952, p = 0.009, ηp2 = 0.742) and calf-circumference (Δ = 0.812 ± 0.128 cm, p < 0.001, ηp2 = 0.863) significantly increased over time. While post-menopausal women demonstrated greater overall arterial stiffness (increased cf-PWV at baseline), there was no difference in cardiovascular response (central or peripheral) to 2-hours of prolonged sitting between the pre- and post-menopausal women.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Prolonged sitting; Arterial stiffness; Menopause; Carotid-femoral pulse wave velocity
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA407 Health status indicators.
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Charlotte Crutchlow
Date Deposited: 07 May 2024 09:11
Last Modified: 18 Jun 2024 12:00

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