The Physiologic Benefits of Optimizing Cardiorespiratory Fitness and Physical Activity – From the Cell to Systems Level in a Post-Pandemic World

Faghy, Mark A, Tatler, Amanda, Chidley, Corinna, Fryer, Simon M ORCID: 0000-0003-0376-0104, Stoner, Lee, Laddu, Deepika, Arena, Ross and Ashton, Ruth E (2024) The Physiologic Benefits of Optimizing Cardiorespiratory Fitness and Physical Activity – From the Cell to Systems Level in a Post-Pandemic World. Progress in Cardiovascular Diseases, 83. pp. 49-54. doi:10.1016/j.pcad.2024.02.006

13778 Faghy et al (2024) The Physiologic Benefits of Optimizing Cardiorespiratory.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (928kB) | Preview


Cardiovascular (CV) disease (CVD) is a leading cause of premature death and hospitalization which places a significant strain on health services and economies around the World. Evidence from decades of empirical and observational research demonstrates clear associations between physical activity (PA) and cardiorespiratory fitness (CRF) which can offset the risk of mortality and increase life expectancy and the quality of life in patients. Whilst well documented, the narrative of increased CRF remained pertinent during the coronavirus disease 2019 (COVID-19) pandemic, where individuals with lower levels of CRF had more than double the risk of dying from COVID-19 compared to those with a moderate or high CRF. The need to better understand the mechanisms associated with COVID-19 and those that continue to be affected with persistent symptoms following infection (Long COVID), and CV health is key if we are to be able to effectively target the use of CRF and PA to improve the lives of those suffering its afflictions. Whilst there is a long way to go to optimise PA and CRF for improved health at a population level, particularly in a post-pandemic world, increasing the understanding using a cellular-to-systems approach, we hope to provide further insight into the benefits of engaging in PA.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Cardiovascular disease; cardio-respiratory fitness; physical activity; COVID-19; Long COVID
Subjects: G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Charlotte Crutchlow
Date Deposited: 28 Feb 2024 10:50
Last Modified: 07 May 2024 10:30

University Staff: Request a correction | Repository Editors: Update this record

University Of Gloucestershire

Bookmark and Share

Find Us On Social Media:

Social Media Icons Facebook Twitter Google+ YouTube Pinterest Linkedin

Other University Web Sites

University of Gloucestershire, The Park, Cheltenham, Gloucestershire, GL50 2RH. Telephone +44 (0)844 8010001.