An exploration into the effects of prolonged sitting on cardiovascular health and the influence of modifiable lifestyle factors

Paterson, Craig ORCID: 0000-0003-3125-9712 (2022) An exploration into the effects of prolonged sitting on cardiovascular health and the influence of modifiable lifestyle factors. PhD thesis, University of Gloucestershire. doi:10.46289/P4S9T25L

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12718 Paterson Craig (2022) An exploration into the effects of prolonged sitting on cardiovascular health and the influence of modifiable lifestyle.pdf - Accepted Version
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Time spent in sedentary behaviours, particularly prolonged sitting, has been identified as an independent risk factor for cardiovascular disease (CVD). However, the physiological mechanisms by which prolonged sitting contributes to CVD burden and what can be done to offset that burden remains unclear. Whilst a working model currently exists, further work is needed. In order to progress the working model, it is first necessary to consolidate the existing literature to identify the likely effect of prolonged sitting on the cardiovascular system. Identifying the impact of prolonged sitting is complicated by the fact that this behaviour is likely to cluster with other modifiable lifestyle behaviours, the most prominent of which are fat consumption, habitual physical activity, and cardiorespiratory fitness. Understanding into how these modifiable lifestyle factors may impact the cardiovascular system in conjunction with prolonged sitting is vital for the development of a robust biologically plausible model. As such, this thesis has two overarching aims: 1) to consolidate the existing evidence related to prolonged sitting, with and without interruption, and certain markers of cardiovascular health and function using systematic review and meta-analytic practices, and 2) to conduct experimental studies to investigate the interactions of prominent modifiable lifestyle factors on cardiovascular responses to bouts of prolonged sitting. This thesis demonstrated that: 1) acute bouts of prolonged uninterrupted sitting negatively impact cardiovascular function, but regularly interrupting bouts of prolonged sitting, particularly with aerobic activities, may offset these negative effects, and, 2) whilst cardiorespiratory fitness and habitual physical activity do not impact the cardiovascular responses to an acute sitting bout, the combined deleterious effects of prolonged sitting and consumption of a high-fat meal can be offset using regular interruptions. Collectively, this thesis identified a robust mechanism by which prolonged sitting contributes to cardiovascular burden, and further, this thesis offers insight into strategies to mitigate cardiovascular dysfunction. Finally, this thesis identified several methodological practices within the research area which should be improved.

Item Type: Thesis (PhD)
Thesis Advisors:
Thesis AdvisorEmailURL
Uncontrolled Keywords: Cardiovascular diseases (CVDs); Sedentary behaviours; Lifestyle behaviours
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Schools and Research Institutes > School of Education and Science
Depositing User: Susan Turner
Date Deposited: 10 May 2023 10:39
Last Modified: 01 Sep 2023 16:02

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