Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review

Sethi, Yashendra, Patel, Neil, Kaka, Nirja, Kaiwan, Oroshay, Kar, Jill, Moinuddin, Arsalan ORCID: 0000-0002-4242-1714, Goel, Ashish, Chopra, Hitesh and Cavalu, Simona (2023) Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review. Journal of Clinical Medicine, 12 (5). Art 1799. doi:10.3390/jcm12051799

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Text 12467 Sethi, Patel, Kaka, Kaiwan, Kar, Moinuddin, Goel, Chopra, Cavaul (2023) Precision medicine and the future of cardiovascular diseases - a clinically oriented comprehensive review.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (2MB) | Preview

Abstract

Cardiac diseases form the lion’s share of the global disease burden, owing to the paradigm shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly doubled, increasing from 271 million in 1990 to 523 million in 2019. Additionally, the global trend for the years lived with disability has doubled, increasing from 17.7 million to 34.4 million over the same period. The advent of precision medicine in cardiology has ignited new possibilities for individually personalized, integrative, and patient-centric approaches to disease prevention and treatment, incorporating the standard clinical data with advanced “omics”. These data help with the phenotypically adjudicated individualization of treatment. The major objective of this review was to compile the evolving clinically relevant tools of precision medicine that can help with the evidence-based precise individualized management of cardiac diseases with the highest DALY. The field of cardiology is evolving to provide targeted therapy, which is crafted as per the “omics”, involving genomics, transcriptomics, epigenomics, proteomics, metabolomics, and microbiomics, for deep phenotyping. Research for individualizing therapy in heart diseases with the highest DALY has helped identify novel genes, biomarkers, proteins, and technologies to aid early diagnosis and treatment. Precision medicine has helped in targeted management, allowing early diagnosis, timely precise intervention, and exposure to minimal side effects. Despite these great impacts, overcoming the barriers to implementing precision medicine requires addressing the economic, cultural, technical, and socio-political issues. Precision medicine is proposed to be the future of cardiovascular medicine and holds the potential for a more efficient and personalized approach to the management of cardiovascular diseases, contrary to the standardized blanket approach.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Precision medicine; Cardiology; Precision cardiology; Hypertension; Heart failure; Myocardial infarction
Subjects:	R Medicine > RA Public aspects of medicine > RA645.A-Z Individual diseases or groups of diseases, A-Z > RA645.C68 Coronary heart disease R Medicine > RB Pathology R Medicine > RC Internal medicine
Divisions:	Schools and Research Institutes > School of Education and Science
Depositing User:	Anna Kerr
Date Deposited:	10 Mar 2023 15:00
Last Modified:	31 Aug 2023 09:06
URI:	https://eprints.glos.ac.uk/id/eprint/12467

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