Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: a randomized, controlled cross-over trial

Fryer, Simon M ORCID: 0000-0003-0376-0104, Paterson, Craig ORCID: 0000-0003-3125-9712, Turner, Louise A ORCID: 0000-0002-0153-7075, Moinuddin, Arsalan ORCID: 0000-0002-4242-1714, Faulkner, James, Stoner, Lee, Daykin, Anne ORCID: 0000-0002-9656-856X and Stone, Keeron J ORCID: 0000-0001-6572-7874 (2023) Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: a randomized, controlled cross-over trial. Frontiers in Physiology, 14. ART 1107456. doi:10.3389/fphys.2023.1107456

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Abstract

Exposure to acute prolonged sitting and consumption of a high fat (HF) meal have been shown to independently and additively impair central and peripheral cardiovascular function. This study sought to determine whether localised activity, namely leg fidgeting, offers a protective effect to these deleterious effects. Using a randomized crossover design with three trials, 18 healthy males sat uninterrupted for 180 min following the consumption of a low fat (LF, trial 1) or HF meal (trial 2). The third trial consisted of a HF meal but sitting was interrupted with 1 min of leg fidgeting (isolated bilateral plantar flexion) consisting of ~250 taps per min every 5 min for the 180 min duration. Carotid-femoral pulse wave velocity (cfPWV), aortic-femoral stiffness gradient (af-SG), superficial femoral blood flow, shear-rate and PWVβ, triglyceride concentrations and lower-limb venous pooling (HHb) were assessed pre and post sitting in all trials. General linear mixed model found that following the uninterrupted HF trial, there was a significant worsening of cfPWV (mean difference (MD)= 0.57 mˑs-1; d= 1.04) and the af-SG (MD= 0.14, d= 0.50), and femoral artery blood flow (MD= 18 mlˑmin-1; d= 0.48) and shear rate (MD= 15 S1; d= 0.67) decreased. However, leg fidgeting was enough to prevent the combined deleterious effects of prolonged sitting following a HF meal. As there were no significant changes in the LF trial, the HF meal maybe the predominant driver when uninterrupted sitting is combined with a HF meal.

Item Type:	Article
Article Type:	Article
Additional Information:	This article is part of the Research Topic Sedentary Behavior and Health Outcomes: Origins, Mechanisms and Policy
Uncontrolled Keywords:	Physiology; CFPWV; Carotid femoral pulse wave velocity; Trygliceride-rich lipoproteins; Leg fidgeting; Uninterrupted sitting; Endothelial function
Subjects:	G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports Q Science > QM Human anatomy R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA645.O23 Body mass. Adult obesity R Medicine > RM Therapeutics. Pharmacology > RM695 Physical medicine. physical therapy including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Anna Kerr
Date Deposited:	18 Jan 2023 09:52
Last Modified:	02 Nov 2023 10:35
URI:	https://eprints.glos.ac.uk/id/eprint/12261

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