Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer

Ye, Lin, Sanders, Andrew J. ORCID: 0000-0002-7997-5286 and Jiang, Wen G. (2023) Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer. Anticancer Research, 43 (1). pp. 291-296. doi:10.21873/anticanres.16162

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Abstract

Transglutaminase-4, also known as prostate transglutaminase, is a protein encoded by the TGM4 gene. TGase-4 was thought to be exclusively expressed in the prostate gland and has been suggested to be involved in certain medical conditions, such as infertility and possibly prostate cancer. In recent years, substantial progress has been made in the understanding of this unique protein in prostate cancer, with emerging clinical evidence. The present concise review summarised the current understanding of this intriguing enzyme in prostate cancer and presents an argument that TGase-4 is a useful indicator of both the development and progression of the disease.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Prostate cancer; Diagnosis; Transglutaminase-4; Prostate transglutaminase; TGM4; Prostate cancer; Metastasis; Review
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Place, Environment and Community
Depositing User:	Susan Turner
Date Deposited:	04 Jan 2023 11:49
Last Modified:	31 Aug 2023 08:57
URI:	https://eprints.glos.ac.uk/id/eprint/12235

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