NUPR1 and its potential role in cancer and pathological conditions (Review)

Martin, Tracey, Li, Amber, Sanders, Andrew ORCID: 0000-0002-7997-5286, Ye, Lin, Frewer, Kathryn, Hargest, Rachel and Jiang, Wen (2021) NUPR1 and its potential role in cancer and pathological conditions (Review). International Journal of Oncology, 58 (5). ART 21. doi:10.3892/ijo.2021.5201

11543 Sanders, Martin, Li, Ye, Frewer, Hargest, Jiang (2021) NUPR1 and its potential role in cancer and pathological conditions (Review).pdf - Published Version
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Nuclear protein‑1 (NUPR1) is also known as Com‑1 or p8. It is a protein primarily found in the nucleus of various cells, including cancer cells, and it has been found to play an important role in cell stress and stress‑related apoptosis. Over the past two decades, NUPR1 has been firmly indicated to play a role in the development and progression of numerous types of cancer, as well as in a number of other pathological conditions, including pancreatitis, diabetes, neurological and inflammatory conditions. The past decade has witnessed a rapid understanding of the biological and cellular mechanisms through which NUPR1 operates on cells and the identification of new variant of the protein. Most importantly, there have been comprehensive studies on the clinical and pathological aspects of NUPR1 and its variant in multiple malignancies and identification of therapeutic methods by targeting the protein. The present review aimed to summarise the current knowledge relating to NUPR1 in human malignancies and to discuss the associated controversies and potential future prospects of this molecule.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: NUPR1; Com‑1; P8; NUPR1‑like; Cancer; NUPR2; Metastasis; Survival; Therapeutics
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Place, Environment and Community
Depositing User: Andy Sanders
Date Deposited: 06 Sep 2022 12:28
Last Modified: 31 Aug 2023 08:57

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