Impact of obesity and SARS-CoV-2 infection: implications for host defence - a living review

Richter, Felix Clemens, Alrubayyi, Aljawharah, Teijeira Crespo, Alicia and Hulin-Curtis, Sarah L. ORCID: 0000-0003-0889-964X (2021) Impact of obesity and SARS-CoV-2 infection: implications for host defence - a living review. Oxford Open Immunology, 2 (1). Art iqab001. doi:10.1093/oxfimm/iqab001

Text (Peer Reviewed Version) 11435 Richter, Alrubayyi, Teijeira Crespo and Hulin-Curtis (2020) Impact_of_Obesity_and_SARS-CoV-2_Infection_Implications_for_host_defence_a_Living_Review.pdf - Published Version Restricted to Repository staff only Available under License Creative Commons Attribution 4.0. Download (356kB)

Abstract

The role of obesity in the pathophysiology of respiratory virus infections has become particularly apparent during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, where obese patients are twice as likely to suffer from severe coronavirus disease 2019 (COVID-19) than healthy weight individuals. Obesity results in disruption of systemic lipid metabolism promoting a state of chronic low-grade inflammation. However, it remains unclear how these underlying metabolic and cellular processes promote severe SARS-CoV-2 infection. Emerging data in SARS-CoV-2 and Influenza A virus (IAV) infections show that viruses can further subvert the host’s altered lipid metabolism and exploit obesity-induced alterations in immune cell metabolism and function to promote chronic inflammation and viral propagation. In this review, we outline the systemic metabolic and immune alterations underlying obesity and discuss how these baseline alterations impact the immune response and disease pathophysiology. A better understanding of the immunometabolic landscape of obese patients may aid better therapies and future vaccine design.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Obesity; SARS-CoV-2; Influenza; Virus; Metabolism; Immune Response; COVID-19; Inflammation
Subjects:	R Medicine > R Medicine (General)
Divisions:	Schools and Research Institutes > School of Health and Social Care
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Sarah Curtis
Date Deposited:	03 Nov 2022 15:47
Last Modified:	08 Nov 2023 16:00
URI:	https://eprints.glos.ac.uk/id/eprint/11435

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