EPLIN Expression in Gastric Cancer and Impact on Prognosis and Chemoresistance

Gong, Wenjing, Zeng, Jianyuan, Ji, Jiafu, Jia, Yongning, Jia, Shuqin, Sanders, Andrew ORCID: 0000-0002-7997-5286 and Jiang, Wen G. (2021) EPLIN Expression in Gastric Cancer and Impact on Prognosis and Chemoresistance. Biomolecules, 11 (4). ART 547. doi:10.3390/biom11040547

11413_Sanders_Gong_Zeng_Ji_Jia_Jia_Jiang_(2021)_EPLIN_expression_in_gastric_cancer_and_impact_on_prognosis_and_chemoresistance.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (6MB) | Preview


Epithelial protein lost in neoplasm (EPLIN) has been implicated as a suppressor of cancer progression. The current study explored EPLIN expression in clinical gastric cancer and its association with chemotherapy resistance. EPLIN transcript expression, in conjunction with patient clinicopathological information and responsiveness to neoadjuvant chemotherapy (NAC), was explored in two gastric cancer cohorts collected from the Beijing Cancer Hospital. Kaplan-Meier survival analysis was undertaken to explore EPLIN association with patient survival. Reduced EPLIN expression was associated with significant or near significant reductions of overall, disease-free, first progression or post-progression survival in the larger host cohort and Kaplan Meier plotter datasets. In the larger cohort EPLIN expression was significantly higher in the combined T1 + T2 gastric cancer group compared to the T3 + T4 group and identified to be an independent prognostic factor of disease-free survival and overall survival by multivariate analysis. In the smaller, NAC cohort, EPLIN expression was found to be significantly lower in tumour tissues than in paratumour tissues. EPLIN expression was significantly associated with responsiveness to chemotherapy which contributes to overall survival. Together, EPLIN appears to be a prognostic factor and may be associated with patient sensitivity to NAC.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: EPLIN; Gastric cancer; Clinicopathology; Prognosis; Chemoresistance
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Schools and Research Institutes > School of Education and Science
Research Priority Areas: Place, Environment and Community
Depositing User: Anna Kerr
Date Deposited: 28 Jul 2022 13:52
Last Modified: 31 Aug 2023 08:57
URI: https://eprints.glos.ac.uk/id/eprint/11413

University Staff: Request a correction | Repository Editors: Update this record

University Of Gloucestershire

Bookmark and Share

Find Us On Social Media:

Social Media Icons Facebook Twitter Google+ YouTube Pinterest Linkedin

Other University Web Sites

University of Gloucestershire, The Park, Cheltenham, Gloucestershire, GL50 2RH. Telephone +44 (0)844 8010001.