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Gong, Wenjing, Zeng, Jianyuan, Ji, Jiafu, Jia, Yongning, Jia, Shuqin, Sanders, Andrew 
ORCID: 0000-0002-7997-5286 and Jiang, Wen G.
(2021)
EPLIN Expression in Gastric Cancer and Impact on Prognosis and Chemoresistance.
Biomolecules, 11 (4).
ART 547.
doi:10.3390/biom11040547
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11413_Sanders_Gong_Zeng_Ji_Jia_Jia_Jiang_(2021)_EPLIN_expression_in_gastric_cancer_and_impact_on_prognosis_and_chemoresistance.pdf - Published Version Available under License Creative Commons Attribution 4.0. Download (6MB) | Preview |
Abstract
Epithelial protein lost in neoplasm (EPLIN) has been implicated as a suppressor of cancer progression. The current study explored EPLIN expression in clinical gastric cancer and its association with chemotherapy resistance. EPLIN transcript expression, in conjunction with patient clinicopathological information and responsiveness to neoadjuvant chemotherapy (NAC), was explored in two gastric cancer cohorts collected from the Beijing Cancer Hospital. Kaplan-Meier survival analysis was undertaken to explore EPLIN association with patient survival. Reduced EPLIN expression was associated with significant or near significant reductions of overall, disease-free, first progression or post-progression survival in the larger host cohort and Kaplan Meier plotter datasets. In the larger cohort EPLIN expression was significantly higher in the combined T1 + T2 gastric cancer group compared to the T3 + T4 group and identified to be an independent prognostic factor of disease-free survival and overall survival by multivariate analysis. In the smaller, NAC cohort, EPLIN expression was found to be significantly lower in tumour tissues than in paratumour tissues. EPLIN expression was significantly associated with responsiveness to chemotherapy which contributes to overall survival. Together, EPLIN appears to be a prognostic factor and may be associated with patient sensitivity to NAC.
| Item Type: | Article |
|---|---|
| Article Type: | Article |
| Uncontrolled Keywords: | EPLIN; Gastric cancer; Clinicopathology; Prognosis; Chemoresistance |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Schools and Research Institutes > School of Education and Science |
| Research Priority Areas: | Place, Environment and Community |
| Depositing User: | Anna Kerr |
| Date Deposited: | 28 Jul 2022 13:52 |
| Last Modified: | 31 Aug 2023 08:57 |
| URI: | https://eprints.glos.ac.uk/id/eprint/11413 |
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