Total and regional body adiposity increases during menopause—evidence from a follow‐up study

Juppi, Hanna‐Kaarina, Sipilä, Sarianna, Fachada, Vasco, Hyvärinen, Matti, Cronin, Neil ORCID: 0000-0002-5332-1188, Aukee, Pauliina, Karppinen, Jari E., Selänne, Harri, Kujala, Urho M., Kovanen, Vuokko, Karvinen, Sira and Laakkonen, Eija K. (2022) Total and regional body adiposity increases during menopause—evidence from a follow‐up study. Aging Cell, 21 (6). e13621. doi:10.1111/acel.13621

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Abstract

For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumula-tion. Excess adiposity, and especially adipose tissue accumulation in the central body region, increases women's risk of cardiovascular and metabolic conditions and affects physical functioning. We investigated the associations between menopausal progres-sion and total and regional body adiposity measured with dual- energy X- ray absorpti-ometry and computed tomography in two longitudinal cohort studies of women aged 47– 55 (n= 230 and 148, mean follow- up times 1.3 ± 0.7 and 3.9 ± 0.2 years, mean baseline BMI 25.5 kg/m2). We also examined associations between menopausal pro -gression and skeletal muscle fiber characteristics, as well as adipose tissue- derived adipokines. Relative increases of 2%– 14% were observed in regional and total body adiposity measures, with a pronounced fat mass increase in the android area (4% and 14% during short- and long- term follow- ups). Muscle fiber oxidative and glycolytic capacities and intracellular adiposity were not affected by menopause, but were dif-ferentially correlated with total and regional body adiposity at different menopausal stages. Menopausal progression and regional adipose tissue masses were positively associated with serum adiponectin and leptin, and negatively associated with resistin levels. Higher diet quality and physical activity level were also inversely associated with several body adiposity measures. Therefore, healthy lifestyle habits before and during menopause might delay the onset of severe metabolic conditions in women.

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Adipokine; Body fat distribution; Longitudinal studies; Obesity; Perimenopause; Physical activity
Depositing User:	Susan Turner
Date Deposited:	12 May 2022 10:26
Last Modified:	27 Sep 2023 08:13
URI:	https://eprints.glos.ac.uk/id/eprint/11082

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