A primer on repeated sitting exposure and the cardiovascular system: considerations for study design, analysis, interpretation, and translation

Stoner, Lee, Barone Gibbs, Bethany, Meyer, Michelle L., Fryer, Simon M ORCID: 0000-0003-0376-0104, Credeur, Daniel, Paterson, Craig ORCID: 0000-0003-3125-9712, Stone, Keeron J ORCID: 0000-0001-6572-7874, Hanson, Erik D, Kowalsky, Robert J, Horiuchi, Masahiro, Mack, Christopher P and Dave, Gaurav (2021) A primer on repeated sitting exposure and the cardiovascular system: considerations for study design, analysis, interpretation, and translation. Frontiers in Cardiovascular Medicine, 8. Art 716938. doi:10.3389/fcvm.2021.716938

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Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is a major societal concern considering the evidence for a strong association between sitting behavior and cardiovascular disease morbidity and mortality. Unsurprisingly, leading public health agencies have begun to advocate “reduction” in sitting behavior. Though, the guidelines are typically vague and non-specific. The lack of specific guidelines for prolonged sitting is attributable to the absence of available evidence to facilitate guideline development. To inform policy, well-designed randomized controlled trials are required to test the efficacy of specific and translatable sitting reduction strategies. To guide the design of randomized controlled trials, this review postulates that several gaps in the literature first need to be filled. Following a general discussion of the importance of sitting behavior to contemporary societies, each of the following are discussed: (i) acute sitting exposure and systems physiology; (ii) recommendations for a systems physiology toolbox; (iii) study design considerations for acute sitting exposure; and (iv) translation of sitting-focused research.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Biological plausibility; Ecological validity; External validity; Internal validity; Methodology; Sedentary behavior; Arterial stiffness; Endothelial function
Subjects: Q Science > QP Physiology
Divisions: Schools and Research Institutes > School of Business, Computing and Social Sciences
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 06 Sep 2021 11:50
Last Modified: 31 Aug 2023 08:24
URI: https://eprints.glos.ac.uk/id/eprint/10116

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