The aortic-femoral arterial stiffness gradient demonstrates good between-day reliability

Stone, Keeron J ORCID: 0000-0001-6572-7874, Fryer, Simon M ORCID: 0000-0003-0376-0104, Faulkner, James, Meyer, Michelle L., Heffernan, Kevin, Zieff, Gabriel, Paterson, Craig ORCID: 0000-0003-3125-9712, Lambrick, Danielle M and Stoner, Lee (2021) The aortic-femoral arterial stiffness gradient demonstrates good between-day reliability. Hypertension Research, 44 (12). pp. 1686-1688. doi:10.1038/s41440-021-00712-3

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Abstract

In a healthy cardiovascular system, arterial stiffness progressively increases from the elastic aorta to the muscular conduit arteries of the periphery. This stiffness gradient permits a gradual attenuation of the forward pressure wave into a smooth consistent blood flow and prevents the transmission of pulsatile forces to the microcirculation and endorgans [1]. However, aging and lifestyle factors may disrupt these beneficial phenomena [2]. In particular, the aorta tends to stiffen, whereas changes in lower-limb arterial stiffness, for example, are less marked [2]. These differential changes in stiffness lead to a reversal of the stiffness gradient, increasing forward pressure transmission, and contributing to end-organ damage [1, 3]. A recent study reported that the stiffness gradient between aortic and lower-limb arterial stiffness provided prognostic information beyond the carotid-femoral pulse-wave velocity (cfPWV), a criterion measure of arterial health [4]. This measure provides a promising opportunity to gain meaningful insight into the hemodynamic integration of the vascular system. However, a measurement must have acceptable precision (reliability) to be of value in clinical and research settings. Therefore, the objective of this study was to estimate the between-day reliability of the aortic-femoral arterial stiffness gradient (af-SG).

Item Type:	Article
Article Type:	Article
Uncontrolled Keywords:	Carotid-femoral pulse wave velocity; Femoral-ankle pulse wave velocity; Pulse wave velocity ratio; Repeatability
Subjects:	Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA645.A-Z Individual diseases or groups of diseases, A-Z > RA645.C68 Coronary heart disease
Divisions:	Schools and Research Institutes > School of Education and Science
Research Priority Areas:	Health, Life Sciences, Sport and Wellbeing
Depositing User:	Rhiannon Goodland
Date Deposited:	05 Aug 2021 15:41
Last Modified:	31 Aug 2023 09:07
URI:	https://eprints.glos.ac.uk/id/eprint/10033

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