Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them

Stones, Daniel H ORCID: 0000-0002-8981-7943 and Krachler, Anne-Marie (2015) Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them. International Journal of Molecular Sciences, 16 (2). pp. 2626-2640. ISSN 1422-0067

[img]
Preview
Text (Published version)
6062 - Stones - 2015 - Fatal attraction.pdf - Published Version
Available under License Creative Commons Attribution 4.0.

Download (2MB) | Preview

Abstract

The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Adhesion; Adhesin; Cell-signaling; Host-pathogen interaction; Bacterial attachment; Anti-adhesion therapy
Subjects: Q Science > QR Microbiology
Divisions: Schools and Research Institutes > School of Natural & Social Sciences
Research Priority Areas: Environmental Dynamics & Governance
Depositing User: Daniel Stones
Date Deposited: 09 Oct 2018 08:53
Last Modified: 11 Oct 2018 04:36
URI: http://eprints.glos.ac.uk/id/eprint/6062

University Staff: Request a correction | Repository Editors: Update this record

University Of Gloucestershire

Bookmark and Share

Find Us On Social Media:

Social Media Icons Facebook Twitter Google+ YouTube Pinterest Linkedin

Other University Web Sites

University of Gloucestershire, The Park, Cheltenham, Gloucestershire, GL50 2RH. Telephone +44 (0)844 8010001.