Wu, Brian and Credeur, Daniel and Fryer, Simon M and Stoner, Lee (2015) The use of shear rate–diameter dose–response curves as an alternative to the flow-mediated dilation test. Medical Hypotheses, 84 (2). pp. 85-90. ISSN 0306-9877
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The brachial artery flow-mediated dilation test (FMD) is the non-invasive gold-standard used to test endothelial function. Reduced FMD precedes the development of atherosclerosis and provides an early marker for predicting future cardiovascular disease events. Although, this test is of high potential, it is somewhat limited by poor reproducibility. By utilizing hand warming and grip exercise combined with hierarchical linear modeling, shear rate–diameter dose–response curves may provide a novel and more accurate way to assess endothelial function in humans. Shear rate–diameter dose–response curves could potentially improve upon the traditional FMD measurement and serve as a superior clinical and research tool for assessing cardiovascular disease risk in a variety of populations. The current paper presents testable hypotheses and methodology for assessing the validity and reliability of an alternative to the current FMD test.
|Uncontrolled Keywords:||Sport physiology|
|Subjects:||Q Science > QP Physiology > QP301.H75 Physiology. Sport
R Medicine > RC Internal medicine > RC1200 Sports Medicine
|Divisions:||Schools and Research Institutes > School of Sport & Exercise > Sport and Exercise|
|Research Priority Areas:||Sport, Exercise, Health & Wellbeing|
|Depositing User:||Anne Pengelly|
|Date Deposited:||20 Jul 2015 13:15|
|Last Modified:||08 Nov 2016 05:36|