The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: A systematic review and meta-analysis

Klaus, Kristel, Butler, Kevin, Curtis, Ffion, Bridle, Chris ORCID: 0000-0003-3986-6680 and Pennington, Kyla (2019) The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 100. pp. 224-236. doi:10.1016/j.neubiorev.2019.01.021

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Abstract

Research in healthy adults suggests that C957T polymorphism of the dopamine D2 receptor encoding DRD2 and the Taq1A polymorphism of the neighbouring gene ankyrin repeat and kinase domain containing 1 (ANKK1) alter dopaminergic signalling and may influence prefrontally-mediated executive functions. A systematic review and meta-analysis was carried out on the evidence for the association of DRD2 C957T and ANKK1 Taq1A polymorphisms in performance on tasks relating to the three core domains of executive function: working memory, response inhibition and cognitive flexibility in healthy adults. CINAHL, MEDLINE, PsycARTICLES and PsychINFO databases were searched for predefined key search terms associated with the two polymorphisms and executive function. Studies were included if they investigated a healthy adult population with the mean age of 18–65 years, no psychiatric or neurological disorder and only the healthy adult arm were included in studies with any case-control design. Data from 17 independent studies were included in meta-analysis, separated by the Taq1A and C957T polymorphisms and by executive function tests: working memory (Taq1A, 6 samples, n = 1270; C957 T, 6 samples, n = 977), cognitive flexibility (C957 T, 3 samples, n = 620), and response inhibition (C957 T, 3 samples, n = 598). The meta-analyses did not establish significant associations between these gene polymorphisms of interest and any of the executive function domains. Theoretical implications and methodological considerations of these findings are discussed.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: ANKK1 Taq1A; DRD2 C957T; Executive function; Working memory; Cognitive flexibility; Response inhibition
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Schools and Research Institutes > School of Health and Social Care
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Susan Turner
Date Deposited: 29 Apr 2024 12:35
Last Modified: 29 Apr 2024 12:38
URI: https://eprints.glos.ac.uk/id/eprint/14020

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