Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized, controlled cross-over trial

Fryer, Simon M ORCID: 0000-0003-0376-0104, Stone, Keeron J ORCID: 0000-0001-6572-7874, Paterson, Craig, Brown, Meghan A ORCID: 0000-0003-3260-977X, Faulkner, James, Lambrick, Danielle M, Credeur, Daniel, Zieff, Gabriel H, Martinez Aguirre-Betolaza, Aitor and Stoner, Lee (2021) Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized, controlled cross-over trial. Hypertension Research. (In Press)

[img] Text (Peer-reviewed version)
9903-Fryer-(2021)-Central-and-peripheral-arterial-stiffness-responses.pdf - Accepted Version
Restricted to Repository staff only (Publisher Embargo).
Available under License All Rights Reserved.

Download (413kB)

Abstract

Background and aims: Independently, prolonged uninterrupted sitting and the consumption of a meal high in saturated fats acutely disrupt normal cardiovascular function. Currently the acute effects of these behaviours performed in combination on arterial stiffness, a marker of cardiovascular health, is unknown. This study sought to determine the effect of consuming a high-fat meal (Δ= 51 g fat) in conjunction with prolonged uninterrupted sitting (180 min) on measures of central and peripheral arterial stiffness. Methods: Using a randomized crossover design, thirteen young healthy males consumed a high-fat (61 g) or low-fat (10 g) meal before 180 min of uninterrupted sitting. Carotid-femoral (cf-) and femoral-ankle (fa-) pulse wave velocity (PWV), aortic-femoral stiffness gradient (af-SG), superficial femoral PWV beta (β), and oscillometric pulse wave analysis outcomes were assessed pre and post sitting. Results: cfPWV increased significantly more following the high-fat (mean difference [MD]= 0.59 m·s-1) when compared to the low-fat (MD= 0.2 m·s-1) meal, with no change in faPWV in either condition. The af-SG significantly decreased (worsened) (ηp2= 0.569) overtime in high and low-fat conditions (ratio= 0.1 and 0.1 respectively). Superficial femoral PWVβ significantly increased over time in high- and low-fat conditions (ηp2= 0.321; 0.8 and 0.4 m·s-1 respectively). A significant interaction found that triglycerides increased over time in the high fat trial only (ηp2= 0.761). There were no significant changes in blood pressures. Conclusions: Consuming a high-fat meal prior to 180 min of uninterrupted sitting augments markers of cardiovascular disease risk more than sitting following a low-fat meal.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Vascular function; Sedentary behaviour; Dietary behaviour; Hypertension
Subjects: G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports
Q Science > QP Physiology
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 29 Jun 2021 11:53
Last Modified: 26 Jul 2021 15:19
URI: http://eprints.glos.ac.uk/id/eprint/9903

University Staff: Request a correction | Repository Editors: Update this record

University Of Gloucestershire

Bookmark and Share

Find Us On Social Media:

Social Media Icons Facebook Twitter Google+ YouTube Pinterest Linkedin

Other University Web Sites

University of Gloucestershire, The Park, Cheltenham, Gloucestershire, GL50 2RH. Telephone +44 (0)844 8010001.