The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults: an Atherosclerosis Risk In Communities (ARIC) study

Stone, Keeron J ORCID: 0000-0001-6572-7874, Fryer, Simon M ORCID: 0000-0003-0376-0104, Faulkner, James, Meyer, Michelle L., Heffernan, Kevin, Kucharska-Newton, Anna, Zieff, Gabriel H, Paterson, Craig, Matsushita, Kunihiro, Hughes, Timothy, Tanaka, Hirofumi and Stoner, Lee (2021) The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults: an Atherosclerosis Risk In Communities (ARIC) study. Journal of Hypertension. (In Press)

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Abstract

Aortic arterial stiffness is a strong independent predictor of cardiovascular disease (CVD), however its dependence on mean arterial pressure (MAP) limits its clinical utility. The aortic-femoral arterial stiffness gradient (af-SG), a novel marker of CVD risk, may be a promising alternative, but its dependence on MAP is not known. The aim of this study was to determine the relationship between MAP and the af-SG in healthy older adults and those with established disease, including hypertension and diabetes. We evaluated the dependency of the af-SG on MAP in healthy older adults (n = 694, aged 74 ± 5 years), and adults with hypertension (n = 2040, aged 76 ± 5 years), and diabetes (n = 1405, aged 75 ± 5 years) as part of the community-based Atherosclerosis Risk in Communities (ARIC) Study. Carotid-femoral pulse-wave velocity (cfPWV), femoral-ankle PWV (faPWV) and blood pressure were measured using standardized protocols. The af-SG was calculated as faPWV divided by cfPWV. Multivariable regression analysis was performed to test the independent association of MAP with af-SG, with adjustments for known confounders including age, sex, body mass index, blood glucose and heart rate. The was no significant relationship between the af-SG and MAP in healthy (β = 0.002, p = .301), hypertension (β = -0.001, p = .298) or diabetes (β = -0.001, p = .063) population groups, with MAP explaining <0.1, <0.1 and 0.2% of the variance in the af-SG, respectively. These findings suggest that the af-SG may be regarded as a MAP independent index of arterial health and CVD risk in older adults.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Arterial stiffness; Pulse wave velocity; Mean arterial pressure; Pulse wave velocity ratio; Cardiovascular disease
Subjects: Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA407 Health status indicators.
R Medicine > RA Public aspects of medicine > RA645.A-Z Individual diseases or groups of diseases, A-Z > RA645.C68 Coronary heart disease
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Rhiannon Goodland
Date Deposited: 15 Jun 2021 10:25
Last Modified: 26 Jul 2021 15:25
URI: http://eprints.glos.ac.uk/id/eprint/9849

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