The pressure-dependency of local measures of arterial stiffness

Zieff, Gabriel H, Heffernan, Kevin, Stone, Keeron J, Fryer, Simon M, Credeur, Daniel, Hanson, Erik D, Faulkner, James and Stoner, Lee (2018) The pressure-dependency of local measures of arterial stiffness. Journal of Hypertension. ISSN 0263-6352 (In Press)

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Objective: To determine which ultrasound-based, single-point arterial stiffness estimate is least dependent on blood pressure to improve assessment of local vascular function. Methods: Ultrasound was used to assess blood flow and diameters at the left brachial artery of twenty healthy adults [55% F, 27.9 y (5.2), 24.2 (2.8) kg/m2]. Blood pressure of both arms was measured simultaneously. Experimental (left) arm blood pressure was then systematically manipulated by adjusting its position ABOVE (+30) and BELOW (-30) heart level in a randomized order following measurement at heart level (0). The control (right) arm remained at heart level. Six stiffness measurements were calculated: compliance, distensibility, beta-stiffness, and three estimates of pulse wave velocity (Bramwell Hill, blood flow, and Beta-stiffness). We considered the measurement technique with the least significant change across positions to be the least pressure-dependent. Results: There was a large effect change in mean arterial pressure (n2p = 0.75, p < 0.001) in the experimental arm when it was ABOVE (∆-4.4 mmHg) and BELOW (∆10.4 mmHg) heart level. There was a main effect (p < 0.05) of arm position on all arterial stiffness measures. From least to most pressure-dependent, the arterial stiffness measurements were: pulse wave velocity (blood flow method), compliance coefficient, beta-stiffness, distensibility coefficient, pulse wave velocity (Bramwell-Hill method), and pulse wave velocity (beta-stiffness index method). Conclusions: All single-point measures assessed are pressure-dependent. The pulse wave velocity (blood flow method) may be the least pressure-dependent single-point measure, and may be the most suitable single-point measure to assess local vascular function.

Item Type: Article
Article Type: Article
Additional Information: Running Title: Pressure-dependency of arterial stiffness
Uncontrolled Keywords: blood pressure, hydrostatic pressure, posture; vascular stiffness; atherosclerosis
Subjects: G Geography. Anthropology. Recreation > GV Recreation Leisure > GV557 Sports
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Anne Pengelly
Date Deposited: 29 Oct 2018 11:10
Last Modified: 19 Mar 2019 17:17

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