Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study

Corres, Pablo, Maldonado-Martin, Sara, Gorostegi-Anduaga, Ilargi, Fryer, Simon M, Jurio-Iriarte, Borja, MartínezAguirre-Betolaza, Aitor, Arratibel-Imaz, Iñaki, Francisco-Terreros, Silvia and Pérez-Asenjo, Javier (2018) Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513 (In Press)

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Abstract

Cardiorespiratory fitness (CRF) is positively associated with enhanced cardiovascular health. This cross-sectional study aimed to determine associations between CRF and the biochemical profile of overweight/obese adults diagnosed with primary hypertension (HTN). Does cardiorespiratory fitness (exposure) positively affect the biochemical profile (outcome) in overweight/obese individuals suffering from HTN? Assessment with anthropometric, ambulatory blood pressure monitoring (24 hours), CRF (peak oxygen uptake, V̇O2peak), and biochemical analysis was performed on 214 participants (138 men, 76 women). A series of linear and logistic regression analyses were conducted. Participants were divided into CRF tertiles (classified as low, moderate, and high CRF). The CRF was independently and inversely associated with aspartate aminotransferase (AST; β=-0.328, P<0.05) and alanine aminotransferase (ALT; β=-0.376, P<0.01) concentrations. C-reactive protein, AST/ALT ratio, gamma-glutamyl transpeptidase, total cholesterol/high-density lipoprotein cholesterol ratio, glucose, insulin and insulin resistance index (HOMA-IR), were all associated, but not independently, with CRF in linear and/or unadjusted logistic regression models. However, independently, logistic regression revealed that glucose was associated with the moderate CRF group. Findings suggest that a lower CRF is associated with an unhealthy biochemical profile in non-physically active and overweight/obese individuals with HTN. As such, this population should look to increase physical activity in order to improve their CRF and biochemical profile.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Cardiorespiratory fitness; Hypertension; Overweight; Aspartate aminotransferase; Alanine aminotransferase
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Susan Turner
Date Deposited: 12 Sep 2018 13:45
Last Modified: 12 Sep 2018 22:16
URI: http://eprints.glos.ac.uk/id/eprint/5940

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