Lesions and classifications of diabetic retinopathy

Scanlon, Peter H ORCID: 0000-0001-8513-710X (2017) Lesions and classifications of diabetic retinopathy. In: Practical Manual of Diabetic Retinopathy Management, 2nd edition. Wiley Blackwell, Oxford, pp. 26-39. ISBN 9781119058953

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Abstract

Diabetic retinopathy refers to pathology of the capillaries, arterioles and venules in the retina and the subsequent effects of leakage from or occlusion of the small vessels. Changes that occur within the retinal capillary wall include: thickening of the basement membrane; pericyte loss; epithelial cell dysfunction (loss of epithelial tight junctions); and loss of endothe‐lial cells. The lesions that the Early Treatment Diabetic Retinopathy Study (ETDRS) described as critical to the stages of progression of diabetic retinopathy are microaneurysm, haemorrhage, and HMas. There are a number of different classifications of diabetic retinopathy which have been developed to give indications of the risks of progression to proliferative diabetic retinopathy or vision‐threatening maculopathy, and the appropriate referral criteria, the latter depending on individual healthcare systems. The key factor in these classifications is accurate identification of the lesions that occur in diabetic retinopathy.

Item Type: Book Section
Additional Information: Chapter 3
Uncontrolled Keywords: Diabetic retinopathy
Subjects: R Medicine > RE Ophthalmology
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Susan Turner
Date Deposited: 20 Aug 2018 11:52
Last Modified: 20 Aug 2018 11:52
URI: http://eprints.glos.ac.uk/id/eprint/5889

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