Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy. Cross-sectional Analyses of Baseline Data of the EUROCONDOR project

Santos, Ana Rita and Ribeiro, Luísa and Bandello, Francesco and Lattanzio, Rosangela and Egan, Catherine and Frydkjaer-Olsen, Ulrik and García-Arumí, José and Gibson, Jonathan and Grauslund DMSci, Jakob and Harding, Simon P and Lang, Gabriele E and Massin, Pascale and Midena, Edoardo and Scanlon, Peter H and Aldington, Stephen J and Simão, Sílvia and Schwartz, Christian and Ponsati, Berta and Porta, Massimo and Costa, Miguel Ângelo and Hernández, Cristina and Cunha-Vaz, José and Simó, Rafael (2017) Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy. Cross-sectional Analyses of Baseline Data of the EUROCONDOR project. Diabetes, 66 (9). pp. 2503-2510. ISSN 0012-1797

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Abstract

Cross-sectional study evaluating the relationship between: a) functional and structural measurements of neurodegeneration in initial stages of diabetic retinopathy (DR); and b) presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of patients with type 2 diabetes (n=449) enrolled in the EUROCONDOR study (NCT01726075). Functional studies by multifocal ERG (mfERG) evaluated neurodysfunction and structural measurements using spectral domain optical-coherence tomography (SD-OCT) evaluated neurodegeneration. The mfERG P1 amplitude was more sensitive than the P1 implicit time (IT), and was lower in patients with ETDRS 20-35 than in patients with ETDRS <20 (p=0.005). In 58% of cases, mfERG abnormalities were present in the absence of visible retinopathy. Correspondence between SD-OCT thinning and mfERG abnormalities was shown in 67% of the eyes with ETDRS <20 and in 83% of the eyes with ETDRS 20-35. Notably, 32% of patients with ETDRS 20-35 presented no abnormalities in mfERG or SD-OCT. We conclude that there is a link between mfERG and SD-OCT measurements which increases with the presence of microvascular impairment. However, in our particular study population (ETDRS ≤ 35) a significant proportion of patients had normal GC-IPL thickness and normal mfERG findings. We raise the hypothesis that neurodegeneration may play a role in the pathogenesis of DR in many, but not in all type 2 diabetic patients.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Diabetic retinopathy; Opthalmology
Related URLs:
Subjects: R Medicine > RE Ophthalmology
Divisions: Schools and Research Institutes > School of Sport & Exercise > Sport and Exercise
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Anne Pengelly
Date Deposited: 15 Sep 2017 10:08
Last Modified: 18 Sep 2017 12:51
URI: http://eprints.glos.ac.uk/id/eprint/4743

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