Prospective Relationship between Hemispheric Lateralisation and CD4+ T Cells in Human Immunodeficiency Virus Type 1

Sumner, Rachel C and Nowicky, Alexander V and Parton, Andrew and Wylock, Carolien and Cserjesi, Renata and Fischler, Benjamin and Lacor, Patrick and Gidron, Yori (2014) Prospective Relationship between Hemispheric Lateralisation and CD4+ T Cells in Human Immunodeficiency Virus Type 1. Neuroimmunomodulation, 21 (1). pp. 31-36. ISSN 1021-7401

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Abstract

Objectives: Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders. Methods: Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication). Results: Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts. Conclusions: Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: CD4, HAART, Hemispheric lateralisation, HIV, Prospective study
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Schools and Research Institutes > School of Health and Social Care > Health and Social Care
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Rachel Sumner
Date Deposited: 25 May 2016 16:32
Last Modified: 18 Mar 2017 04:54
URI: http://eprints.glos.ac.uk/id/eprint/3546

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