There's More to Flow-Mediated Dilation Than Nitric Oxide

Stoner, Lee and Erickson, Melissa Lynn and Young, Joanna Mary and Fryer, Simon M and Sabatier, Manning Joseph and Faulkner, James and Lambrick, Danielle Marie and McCully, Kevin Kane (2012) There's More to Flow-Mediated Dilation Than Nitric Oxide. Journal of Atherosclerosis and Thrombosis, 19 (7). pp. 589-600. ISSN 1340-3478

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Abstract

Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Endothelium, FMD, Shear stress, Prostacyclin, Endothelial-derived hyperpolarizing factor, Cardiovascular disease
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Sport & Exercise > Sport and Exercise
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Anne Pengelly
Date Deposited: 20 Jul 2015 14:50
Last Modified: 10 Mar 2016 13:23
URI: http://eprints.glos.ac.uk/id/eprint/2476

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