There's More to Flow-Mediated Dilation Than Nitric Oxide

Stoner, Lee, Erickson, Melissa Lynn, Young, Joanna Mary, Fryer, Simon M, Sabatier, Manning Joseph, Faulkner, James, Lambrick, Danielle Marie and McCully, Kevin Kane (2012) There's More to Flow-Mediated Dilation Than Nitric Oxide. Journal of Atherosclerosis and Thrombosis, 19 (7). pp. 589-600. ISSN 1340-3478

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Abstract

Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Endothelium, FMD, Shear stress, Prostacyclin, Endothelial-derived hyperpolarizing factor, Cardiovascular disease
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Schools and Research Institutes > School of Sport and Exercise > Applied Sport & Exercise Sciences
Research Priority Areas: Sport, Exercise, Health & Wellbeing
Depositing User: Anne Pengelly
Date Deposited: 20 Jul 2015 14:50
Last Modified: 10 Mar 2016 13:23
URI: http://eprints.glos.ac.uk/id/eprint/2476

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