Stoner, Lee and Erickson, Melissa Lynn and Young, Joanna Mary and Fryer, Simon M and Sabatier, Manning Joseph and Faulkner, James and Lambrick, Danielle Marie and McCully, Kevin Kane (2012) There's More to Flow-Mediated Dilation Than Nitric Oxide. Journal of Atherosclerosis and Thrombosis, 19 (7). pp. 589-600. ISSN 1340-3478Full text not available from this repository.
Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.
|Uncontrolled Keywords:||Endothelium, FMD, Shear stress, Prostacyclin, Endothelial-derived hyperpolarizing factor, Cardiovascular disease|
|Subjects:||R Medicine > RC Internal medicine > RC1200 Sports Medicine|
|Divisions:||Schools and Research Institutes > School of Sport & Exercise > Sport and Exercise|
|Research Priority Areas:||Sport, Exercise, Health & Wellbeing|
|Depositing User:||Anne Pengelly|
|Date Deposited:||20 Jul 2015 14:50|
|Last Modified:||10 Mar 2016 13:23|