Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Ghezzi, Silvia, Cooper, Lynsay C ORCID: 0000-0002-5100-5261, Rubio, Alicia, Pagani, Isabel, Capobianchi, Maria R, Ippolito, Giuseppe, Pelletier, Julien, Meneghetti, Maria C, Lima, Marcelo A., Skidmore, Mark A., Broccoli, Vania, Yates, Edwin A. and Vicenzi, Elisa (2017) Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140. pp. 13-17. doi:10.1016/j.antiviral.2016.12.023

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Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Zika virus (ZIKV); Neural progenitor cells; Heparin; Cell death
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Schools and Research Institutes > School of Natural & Social Sciences > Environmental Sciences
Research Priority Areas: Health, Life Sciences, Sport and Wellbeing
Depositing User: Lynsay Cooper
Date Deposited: 25 Aug 2021 14:09
Last Modified: 25 Aug 2021 14:09
URI: http://eprints.glos.ac.uk/id/eprint/10072

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