Glycosaminoglycans from Litopenaeus vannamei inhibit the Alzheimer’s Disease β secretase, BACE1

Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C ORCID: 0000-0002-5100-5261, Guimond, Scott E., Procter, Patricia, Guerrini, Marco, Miller, Gavin J., Fernig, David G., Yates, Edwin A., Lima, Marcelo A. and Skidmore, Mark A. (2021) Glycosaminoglycans from Litopenaeus vannamei inhibit the Alzheimer’s Disease β secretase, BACE1. Marine Drugs, 19 (4). p. 203. doi:10.3390/md19040203

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Abstract

Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The widely used clinical anticoagulant heparin has been reported to exert beneficial effects through multiple pathophysiological pathways involved in the aetiology of Alzheimer’s Disease, for example, amyloid peptide production and clearance, tau phosphorylation, inflammation and oxidative stress. Despite the therapeutic potential of heparin as a multi-target drug for Alzheimer’s disease, the repurposing of pharmaceutical heparin is proscribed owing to the potent anticoagulant activity of this drug. Here, a heterogenous non-anticoagulant glycosaminoglycan extract, obtained from the shrimp Litopenaeus vannamei, was found to inhibit the key neuronal β-secretase, BACE1, displaying a more favorable therapeutic ratio compared to pharmaceutical heparin when anticoagulant activity is considered.

Item Type: Article
Article Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Amyloid-β; BACE1; β-secretase; Glycosaminoglycan; Chondroitin sulfate; Heparin; Heparan sulphate; Litopenaeus vannamei
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Schools and Research Institutes > School of Natural & Social Sciences > Environmental Sciences
Research Priority Areas: Place, Environment and Community
Depositing User: Lynsay Cooper
Date Deposited: 24 Aug 2021 11:01
Last Modified: 24 Aug 2021 11:15
URI: http://eprints.glos.ac.uk/id/eprint/10067

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